Development of an Improved 3D in vitro Intestinal Model to Perform Permeability Studies of Paracellular Compounds.

ABSTRACT: The small intestine is the primary site of drug absorption following oral administration, making paramount the proper monitoring of the absorption process. In vitro tools to predict intestinal absorption are particularly important in preclinical drug development since they are less laborious and cost-intensive and raise less ethical considerations compared to in vivo studies. The Caco-2 model is considered the gold standard of in vitro intestinal models regarding the prediction of absorption of orally delivered compounds. However, this model presents several drawbacks, such as the expression of tighter tight junctions, not being suitable to perform permeability of paracellular compounds. Besides, cells are representative of only one intestinal cell type, without consid

SUBMITTER: Macedo MH 

PROVIDER: S-EPMC7527803 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature