Organophosphorus Nerve Agents: Types, Toxicity, and Treatments.

ABSTRACT: Organophosphorus compounds are extensively used worldwide as pesticides which cause great hazards to human health. Nerve agents, a subcategory of the organophosphorus compounds, have been produced and used during wars, and they have also been used in terrorist activities. These compounds possess physiological threats by interacting and inhibiting acetylcholinesterase enzyme which leads to the cholinergic crisis. After a general introduction, this review elucidates the mechanisms underlying cholinergic and noncholinergic effects of organophosphorus compounds. The conceivable treatment strategies for organophosphate poisoning are different types of bioscavengers which include stoichiometric, catalytic, and pseudocatalytic. The current research on the promising treatments specifically the cat

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC7527902 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature