Indications for Total Gastrectomy in CDH1 Mutation Carriers and Outcomes of Risk-Reducing Minimally Invasive and Open Gastrectomies.

ABSTRACT:

Importance

CDH1 variants are increasingly identified on commercially available multigene panel tests, calling for data to inform counseling of individuals without a family history of gastric cancer.

Objectives

To assess association between CDH1 variant pathogenicity or family history of gastric or lobular breast cancer and identification of signet ring cell cancer and to describe outcomes of risk-reducing minimally invasive and open total gastrectomy.

Design, setting, and participants

This cohort study was performed from January 1, 2006, to January 1, 2020, in 181 patients with CDH1 germline variants from a single institution.

Interventions

Genetic counseling, esophagogastroduodenoscopy, and possible total gastrectomy.

Main outcomes and measures

CDH1 var

SUBMITTER: Vos EL 

PROVIDER: S-EPMC7527942 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature