Association of Early-Life Mental Health With Biomarkers in Midlife and Premature Mortality: Evidence From the 1958 British Birth Cohort.

ABSTRACT:

Importance

Early-life mental health is known to be associated with socioeconomic adversity and psychological distress in adulthood, but less is known about potential associations with biomarkers and mortality.

Objective

To investigate the association between early-life mental health trajectories with biomarkers in midlife and premature mortality.

Design, setting, and participants

This study used data from the British National Child Development Study, a population-based birth cohort. The initial sample of 17 415 individuals consisted of all infants born in Great Britain in a single week in 1958. Analysis began Feburary 2017 and ended May 2020.

Main outcomes and measures

Biomarkers collected at age 44 to 45 years were fibrinogen, C-reactive protein, glycated hemo

SUBMITTER: Ploubidis GB 

PROVIDER: S-EPMC7527946 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature