Pax6 modulates intra-retinal axon guidance and fasciculation of retinal ganglion cells during retinogenesis.

ABSTRACT: Intra-retinal axon guidance involves a coordinated expression of transcription factors, axon guidance genes, and secretory molecules within the retina. Pax6, the master regulator gene, has a spatio-temporal expression typically restricted till neurogenesis and fate-specification. However, our observation of persistent expression of Pax6 in mature RGCs led us to hypothesize that Pax6 could play a major role in axon guidance after fate specification. Here, we found significant alteration in intra-retinal axon guidance and fasciculation upon knocking out of Pax6 in E15.5 retina. Through unbiased transcriptome profiling between Pax6^fl/fl and Pax6^-/- retinas, we revealed the mechanistic insight of its role in axon guidance. Our results showed a significant increase in the

SUBMITTER: Lalitha S 

PROVIDER: S-EPMC7527980 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature