A metagenome-wide association study of gut microbiome and visceral fat accumulation.

ABSTRACT:

Purpose

Visceral fat is an independent risk factor for metabolic and cardiovascular disease. The study aimed to investigate the associations between gut microbiome and visceral fat.

Methods

We recruited 32 obese adults and 30 healthy controls at baseline. Among the obese subjects, 14 subjects underwent laparoscopic sleeve gastrectomy (LSG) and were followed 6 months after surgery. Abdominal visceral fat area (VFA) and subcutaneous fat area (SFA) were measured by magnetic resonance imaging. Waist, hipline, waist-to-hip ratio (WHR) and body mass index (BMI) were included as simple obese parameters. Gut microbiome was analyzed by metagenomic sequencing.

Results

Among the obese parameters, VFA had the largest number of correlations with the species that were differentiall

SUBMITTER: Nie X 

PROVIDER: S-EPMC7528071 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature