Drugs with anti-inflammatory effects to improve outcome of traumatic brain injury: a meta-analysis.

ABSTRACT: Outcome after traumatic brain injury (TBI) varies largely and degree of immune activation is an important determinant factor. This meta-analysis evaluates the efficacy of drugs with anti-inflammatory properties in improving neurological and functional outcome. The systematic search following PRISMA guidelines resulted in 15 randomized placebo-controlled trials (3734 patients), evaluating progesterone, erythropoietin and cyclosporine. The meta-analysis (15 studies) showed that TBI patients receiving a drug with anti-inflammatory effects had a higher chance of a favorable outcome compared to those receiving placebo (RR = 1.15; 95% CI 1.01-1.32, p = 0.041). However, publication bias was indicated together with heterogeneity (I² = 76.59%). Stratified analysis showed that positive ef

SUBMITTER: Begemann M 

PROVIDER: S-EPMC7528105 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature