Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
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ABSTRACT:
SUBMITTER: Vinuela A
PROVIDER: S-EPMC7528108 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Genetic variant effects on gene expression in human pancreatic islets and their implications for T2D.
Viñuela Ana A Varshney Arushi A van de Bunt Martijn M Prasad Rashmi B RB Asplund Olof O Bennett Amanda A Boehnke Michael M Brown Andrew A AA Erdos Michael R MR Fadista João J Hansson Ola O Hatem Gad G Howald Cédric C Iyengar Apoorva K AK Johnson Paul P Krus Ulrika U MacDonald Patrick E PE Mahajan Anubha A Manning Fox Jocelyn E JE Narisu Narisu N Nylander Vibe V Orchard Peter P Oskolkov Nikolay N Panousis Nikolaos I NI Payne Anthony A Stitzel Michael L ML Vadlamudi Swarooparani S Welch Ryan R Collins Francis S FS Mohlke Karen L KL Gloyn Anna L AL Scott Laura J LJ Dermitzakis Emmanouil T ET Groop Leif L Parker Stephen C J SCJ McCarthy Mark I MI
Nature communications 20200930 1
Most signals detected by genome-wide association studies map to non-coding sequence and their tissue-specific effects influence transcriptional regulation. However, key tissues and cell-types required for functional inference are absent from large-scale resources. Here we explore the relationship between genetic variants influencing predisposition to type 2 diabetes (T2D) and related glycemic traits, and human pancreatic islet transcription using data from 420 donors. We find: (a) 7741 cis-eQTLs ...[more]
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