Fluorescence Quenchers Manipulate the Peroxidase-like Activity of Gold-Based Nanomaterials.

ABSTRACT: Although the regulation of the enzyme-like activities of nanozymes has stimulated great interest recently, the exploration of modulators makes it possible to enhance the catalytic performance of nanozymes, though doing so remains a big challenge. Herein, we systemically studied the effects of fluorescence quenchers on the peroxidase-like activity of bovine serum albumin-stabilized gold nanoclusters (BSA-AuNCs) based on photoinduced electron transfer (PET). We found that PET quenchers can not only quench the fluorescence of BSA-AuNCs but also regulate their intrinsic peroxidase-like activity. Importantly, both BSA and human serum albumin (HSA) could enhance the peroxidase-like activity of Cu²⁺, which provided a new sensing platform for distinguishing BSA and HSA from other thiol-

SUBMITTER: Chen YS 

PROVIDER: S-EPMC7528283 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature