Juvenile Huntington's disease: two case reports and a review of the literature.

ABSTRACT:

Background

Huntington's disease is a rare, autosomal dominant neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms. Usually, the disease symptoms first appear around the age of 40, but in 5-10% of cases, they manifest before the age of 21. This is then referred to as juvenile Huntington's disease. According to the small number of cases reported in the literature, the course of juvenile Huntington's disease significantly differs from adult onset and shows significant interpatient variability, making every case unique.

Case presentation

Our study aims to highlight the complexity and diversity of rare juvenile Huntington's disease. We report cases of two Caucasian patients with chronic tics referred to the Huntington's Disease Competence Center

SUBMITTER: Lesinskiene S 

PROVIDER: S-EPMC7528384 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature