Serum protein biomarkers for juvenile dermatomyositis: a pilot study.

ABSTRACT:

Background

Blood accessible biomarkers to assess disease activity and their response to therapies in Juvenile Dermatomyositis (JDM) are urgently needed. This pilot study aims to identify serum protein biomarkers associated with clinical disease activity in untreated JDM and their response to medical therapy.

Methods

SomaScan® technology screened JDM patients for 1305 proteins at three points: 1) before start of treatment, 2) while on therapy, and 3) after treatment tapering when patients were clinically inactive. To define disease associated biomarkers, SomaScan® data from untreated JDM patients (n = 8) were compared to SomaScan® data from an independent age-matched healthy control group (n = 12). Longitudinal analysis defined treatment responsive proteins at t

SUBMITTER: Tawalbeh SM 

PROVIDER: S-EPMC7528471 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature