Cerebrospinal fluid proteome evaluation in major depressive disorder by mass spectrometry.

ABSTRACT:

Background

Depression affects approximately 7.1% of the United States population every year and has an annual economic burden of over $210 billion dollars. Several recent studies have sought to investigate the pathophysiology of depression utilizing focused cerebrospinal fluid (CSF) and serum analysis. Inflammation and metabolic dysfunction have emerged as potential etiological factors from these studies. A dysregulation in the levels of inflammatory proteins such as IL-12, TNF, IL-6 and IFN-γ have been found to be significantly correlated with depression.

Methods

CSF samples were obtained from 15 patients, seven with major depressive disorder and eight age- and gender-matched non-psychiatric controls. CSF protein profiles were obtained using quantitative mass spectrometry.

SUBMITTER: Franzen AD 

PROVIDER: S-EPMC7528485 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature