The genetic architecture of the association between eating behaviors and obesity: combining genetic twin modeling and polygenic risk scores.

ABSTRACT:

Background

Obesity susceptibility genes are highly expressed in the brain suggesting that they might exert their influence on body weight through eating-related behaviors.

Objectives

To examine whether the genetic susceptibility to obesity is mediated by eating behavior patterns.

Methods

Participants were 3977 twins (33% monozygotic, 56% females), aged 31-37 y, from wave 5 of the FinnTwin16 study. They self-reported their height and weight, eating behaviors (15 items), diet quality, and self-measured their waist circumference (WC). For 1055 twins with genome-wide data, we constructed a polygenic risk score for BMI (PRSBMI) using almost 1 million single nucleotide polymorphisms. We used principal component analyses to identify eating behavior patterns, twin modeling to

SUBMITTER: Masip G 

PROVIDER: S-EPMC7528566 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature