Chronic hypoxaemia and gender status modulate adiponectin plasmatic level and its multimer proportion in severe COPD patients: new endotypic presentation?

ABSTRACT:

Background

Disease progression in COPD patient is associated to lung function decline, leading to a higher risk of hypoxaemia and associated comorbidities, notably cardiovascular diseases (CVD). Adiponectin (Ad) is an adipokine with cardio-protective properties. In COPD patients, conflicting results were previously reported regarding Ad plasmatic (Ad_pl) level, probably because COPD is a heterogeneous disease with multifactorial influence. Among these factors, gender and hypoxaemia could interact in a variety of ways with Ad pathway. Therefore, we postulated that these components could influence Ad_pl level and its multimers in COPD patients and contribute to the appearance of a distinct endotype associated to an altered CVD risk.

Methods

One hundred COPD

SUBMITTER: Pierard M 

PROVIDER: S-EPMC7528580 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature