A Network Pharmacological Approach to Investigate the Mechanism of Action of Active Ingredients of Epimedii Herba and Their Potential Targets in Treatment of Alzheimer's Disease.

ABSTRACT: BACKGROUND Epimedii Herba is a traditional Chinese herbal medicine used to treat central nervous system diseases such as Alzheimer's disease in China. However, the pharmacological mechanism is unclear. To investigate the mechanisms of Epimedii Herba in the treatment of Alzheimer's disease, we assessed effective compounds, corresponding targets, and related pathways of Epimedii Herba in the treatment of Alzheimer's disease based on network pharmacology. MATERIAL AND METHODS The active components and targets of Epimedii Herba were obtained through the TCMSP database and the DrugBank database. The DisGeNET database and GeneCards database were used to search for Alzheimer's disease targets. The common targets of components and disease were obtained by Wayne diagram. Gene ontology (GO) analysis

SUBMITTER: Li Y 

PROVIDER: S-EPMC7528617 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature