Optimal Oxygen Targets in Term Lambs with Meconium Aspiration Syndrome and Pulmonary Hypertension.

ABSTRACT: Optimal oxygen saturation as measured by pulse oximetry (Sp_O2) in neonatal lung injury, such as meconium aspiration syndrome (MAS) and persistent pulmonary hypertension of newborn (PPHN), is not known. Our goal was to determine the Sp_O2 range in lambs with MAS and PPHN that results in the highest brain oxygen delivery (bDO₂) and pulmonary blood flow (Qp) and the lowest pulmonary vascular resistance and oxidative stress. Meconium was instilled into endotracheal tubes in 25 near-term gestation lambs, and the umbilical cord was occluded to induce asphyxia and gasping, causing MAS and PPHN. Lambs were randomized into four groups and ventilated for 6 hours with fixed fraction of inspired oxygen (Fi_O2) = 1.0 irrespectiv

SUBMITTER: Rawat M 

PROVIDER: S-EPMC7528912 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature