Germline polymorphisms associated with impaired survival outcomes and somatic tumor alterations in advanced prostate cancer.

ABSTRACT:

Introduction

Germline variants in androgen metabolism genes may influence clinical response to androgen deprivation therapy (ADT) in advanced prostate cancer. We sought to investigate the prognostic significance of germline variants in androgen metabolism genes with respect to overall survival (OS) after ADT, and to associate germline variants with tumor genomic features.

Methods

Germline and somatic whole-genome sequencing (WGS) data were evaluated in a cohort of 101 men with metastatic castration-resistant prostate cancer (mCRPC). Survival analyses were performed to identify polymorphisms associated with impaired OS after primary ADT. Germline variants found to be prognostic of OS were associated with tumor somatic DNA-sequence alterations based on WGS performed on paired

SUBMITTER: Chen WS 

PROVIDER: S-EPMC7529063 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature