Determining real-time mass deposition with a quartz crystal microbalance in an electrostatic, parallel-flow, air-liquid interface exposure system.

ABSTRACT: In vitro studies are the first step toward understanding the biological effects of particulate matter. As a more realistic exposure strategy than submerged culture approaches, air-liquid interface (ALI) in vitro exposure systems are gaining interest. One challenge with ALI systems is determining accurate particle mass deposition. Although a few commercially available ALI systems are equipped with online mass deposition monitoring, most studies use indirect methods to estimate mass doses. These different indirect methods may contribute to inconsistencies in the results from in vitro studies of aerosolized nanoparticles. This study explored the effectiveness of using a commercially available Quartz Crystal Microbalance (QCM) to estimate the real-time, particle-mass deposition inside an elect

SUBMITTER: Kaur K 

PROVIDER: S-EPMC7529104 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature