A 30% incidence of renal cysts with varying sizes and densities in biomedical research swine is not associated with renal dysfunction.

ABSTRACT:

Background

Renal cystic disease arising from various etiologies results in fluid-filled cavities within the kidneys. Moreover, preexisting renal dysfunction has been shown to exacerbate multiple pathologies. While swine bred for biomedical research are often clinically inspected for illness/parasites, more advanced diagnostics may aid in uncovering underlying renal abnormalities.

Methods

Computed tomography was performed in 54 female prepubertal Yorkshire swine to characterize renal cysts; urine and blood chemistry, and histology of cysts were also performed.

Results

Digital reconstruction of right and left kidneys demonstrated that roughly one-third of the animals (17/54; 31%) had one or more renal cyst. Circulating biomarkers of renal function were not different bet

SUBMITTER: Gomez BI 

PROVIDER: S-EPMC7529335 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature