Plasma ACE2 and risk of death or cardiometabolic diseases: a case-cohort analysis.

ABSTRACT:

Background

Angiotensin-converting enzyme 2 (ACE2) is an endogenous counter-regulator of the renin-angiotensin hormonal cascade. We assessed whether plasma ACE2 concentrations were associated with greater risk of death or cardiovascular disease events.

Methods

We used data from the Prospective Urban Rural Epidemiology (PURE) prospective study to conduct a case-cohort analysis within a subset of PURE participants (from 14 countries across five continents: Africa, Asia, Europe, North America, and South America). We measured plasma concentrations of ACE2 and assessed potential determinants of plasma ACE2 levels as well as the association of ACE2 with cardiovascular events.

Findings

We included 10 753 PURE participants in our study. Increased concentration of plasma ACE2 w

SUBMITTER: Narula S 

PROVIDER: S-EPMC7529405 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature