Systematic Assessment of Tumor Purity and Its Clinical Implications.

ABSTRACT:

Purpose

The tumor microenvironment is complex, comprising heterogeneous cellular populations. As molecular profiles are frequently generated using bulk tissue sections, they represent an admixture of multiple cell types (including immune, stromal, and cancer cells) interacting with each other. Therefore, these molecular profiles are confounded by signals emanating from many cell types. Accurate assessment of residual cancer cell fraction is crucial for parameterization and interpretation of genomic analyses, as well as for accurately interpreting the clinical properties of the tumor.

Materials and methods

To benchmark cancer cell fraction estimation methods, 10 estimators were applied to a clinical cohort of 333 patients with prostate cancer. These methods include gold-stand

SUBMITTER: Haider S 

PROVIDER: S-EPMC7529507 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature