Practical Challenges-Use of Paracetamol in Children and Youth Who are Overweight or Obese: A Narrative Review.

ABSTRACT: Worldwide, > 380 million children and adolescents are overweight or obese, including 41 million children aged < 5 years. Obesity can change the pharmacokinetic properties of drugs by altering their distribution, metabolism, and elimination. Thus, children who are overweight or obese are at increased risk for receiving inappropriate doses of commonly used drugs, which can result in treatment failure, adverse events, and/or drug toxicity. This review analyzes available data on paracetamol dosing for pain and fever in children and adolescents who are overweight or obese to identify gaps and challenges in optimal dosing strategies. Literature searches using Medline, Embase, and ClinicalTrials.gov were conducted to identify English-language articles reporting paracetamol pharmacokinetics, dosin

SUBMITTER: Zempsky WT 

PROVIDER: S-EPMC7529628 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature