Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study.

ABSTRACT:

Rationale & objective

Biomarkers that provide reliable evidence of future diabetic kidney disease (DKD) are needed to improve disease management. In a cross-sectional study, we previously identified 13 urine metabolites that had levels reduced in DKD compared with healthy controls. We evaluated associations of these 13 metabolites with future DKD progression.

Study design

Prospective cohort.

Setting & participants

1,001 Chronic Renal Insufficiency Cohort (CRIC) participants with diabetes with estimated glomerular filtration rates (eGFRs) between 20 and 70mL/min/1.73m² were followed up prospectively for a median of 8 (range, 2-10) years.

Predictors

13 urine metabolites, age, race, sex, smoked more than 100 cigarettes in lifetime, body mass index, hemo

SUBMITTER: Kwan B 

PROVIDER: S-EPMC7529642 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature