Radiomic Features of Primary Rectal Cancers on Baseline T₂ -Weighted MRI Are Associated With Pathologic Complete Response to Neoadjuvant Chemoradiation: A Multisite Study.

ABSTRACT:

Background

Twenty-five percent of rectal adenocarcinoma patients achieve pathologic complete response (pCR) to neoadjuvant chemoradiation and could avoid proctectomy. However, pretreatment clinical or imaging markers are lacking in predicting response to chemoradiation. Radiomic texture features from MRI have recently been associated with therapeutic response in other cancers.

Purpose

To construct a radiomics texture model based on pretreatment MRI for identifying patients who will achieve pCR to neoadjuvant chemoradiation in rectal cancer, including validation across multiple scanners and sites.

Study type

Retrospective.

Subjects

In all, 104 rectal cancer patients staged with MRI prior to long-course chemoradiation followed by proctectomy; curated from three i

SUBMITTER: Antunes JT 

PROVIDER: S-EPMC7529659 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature