Alleviation of methyl isocyanate-induced airway obstruction and mortality by tissue plasminogen activator.

ABSTRACT: Methyl isocyanate (MIC, "Bhopal agent") is a highly reactive, toxic industrial chemical. Inhalation of high levels (500-1000 ppm) of MIC vapor is almost uniformly fatal. No therapeutic interventions other than supportive care have been described that can delay the onset of illness or death due to MIC. Recently, we found that inhalation of MIC caused the appearance of activated tissue factor in circulation with subsequent activation of the coagulation cascade. Herein, we report that MIC exposure (500 ppm for 30 min, nose-only) caused deposition of fibrin-rich casts in the conducting airways resulting in respiratory failure and death within 24 h in a rat model (LC_90-100 ). We thus investigated the effect of airway delivery of the fibrinolytic agent tissue plasminogen activator (tP

SUBMITTER: Nick HJ 

PROVIDER: S-EPMC7529679 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature