Molecular Signature of Pruriceptive MrgprA3⁺ Neurons.

ABSTRACT: Itch, initiated by the activation of sensory neurons, is associated frequently with dermatological diseases. MrgprA3⁺ sensory neurons have been identified as one of the major itch-sensing neuronal populations. Mounting evidence has demonstrated that peripheral pathological conditions induce physiological regulation of sensory neurons, which is critical for the maintenance of chronic itch sensation. However, the underlying molecular mechanisms are not clear. Here, we performed RNA sequencing of genetically labeled MrgprA3⁺ neurons under both naïve and allergic contact dermatitis conditions. Our results revealed the unique molecular signature of itch-sensing neurons and the distinct transcriptional profile changes that result in response to dermatitis. We found enrichme

SUBMITTER: Xing Y 

PROVIDER: S-EPMC7529694 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature