Deep longitudinal multiomics profiling reveals two biological seasonal patterns in California.

ABSTRACT: The influence of seasons on biological processes is poorly understood. In order to identify biological seasonal patterns based on diverse molecular data, rather than calendar dates, we performed a deep longitudinal multiomics profiling of 105 individuals over 4 years. Here, we report more than 1000 seasonal variations in omics analytes and clinical measures. The different molecules group into two major seasonal patterns which correlate with peaks in late spring and late fall/early winter in California. The two patterns are enriched for molecules involved in human biological processes such as inflammation, immunity, cardiovascular health, as well as neurological and psychiatric conditions. Lastly, we identify molecules and microbes that demonstrate different seasonal patterns in insulin sen

SUBMITTER: Sailani MR 

PROVIDER: S-EPMC7529769 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature