Exploring celiac disease candidate pathways by global gene expression profiling and gene network cluster analysis.

ABSTRACT: Celiac disease (CeD) is a gastrointestinal autoimmune disorder, whose specific molecular basis is not yet fully interpreted. Therefore, in this study, we compared the global gene expression profile of duodenum tissues from CeD patients, both at the time of disease diagnosis and after two years of the gluten-free diet. A series of advanced systems biology approaches like differential gene expression, protein-protein interactions, gene network-cluster analysis were deployed to annotate the candidate pathways relevant to CeD pathogenesis. The duodenum tissues from CeD patients revealed the differential expression of 106 up- and 193 down-regulated genes. The pathway enrichment of differentially expressed genes (DEGs) highlights the involvement of biological pathways related to loss of cell div

SUBMITTER: Banaganapalli B 

PROVIDER: S-EPMC7529771 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature