Corticosteroids to prevent kidney scarring in children with a febrile urinary tract infection: a randomized trial.

ABSTRACT:

Background

To evaluate the efficacy of adjuvant systemic corticosteroids in reducing kidney scarring. A previous study suggested that use of adjuvant systemic corticosteroids reduces kidney scarring in children radiologically confirmed to have extensive pyelonephritis. Efficacy of corticosteroids for children with febrile urinary tract infection (UTI) has not been studied.

Methods

Children aged 2 months to 6 years with their first febrile UTI were randomized to corticosteroids or placebo for 3 days (both arms received antimicrobial therapy); kidney scarring was assessed using ^99mTc-dimercaptosuccinic acid kidney scan 5-24 months after the initial UTI.

Results

We randomized 546 children of which 385 had a UTI and 254 had outcome kidney scans (instead of the

SUBMITTER: Shaikh N 

PROVIDER: S-EPMC7529851 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature