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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.

ABSTRACT: Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and how PRMT-mediated non-histone arginine methylation modulates various diseases. Additionally, we highlight the most recent clinical studies for several PRMT inhibitors.

SUBMITTER: Al-Hamashi AA 

PROVIDER: S-EPMC7529871 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Non-Histone Arginine Methylation by Protein Arginine Methyltransferases.

Al-Hamashi Ayad A AA   Diaz Krystal K   Huang Rong R  

Current protein & peptide science 20200101 7

Protein arginine methyltransferase (PRMT) enzymes play a crucial role in RNA splicing, DNA damage repair, cell signaling, and differentiation. Arginine methylation is a prominent posttransitional modification of histones and various non-histone proteins that can either activate or repress gene expression. The aberrant expression of PRMTs has been linked to multiple abnormalities, notably cancer. Herein, we review a number of non-histone protein substrates for all nine members of human PRMTs and  ...[more]

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