Microbiota-derived metabolite promotes HDAC3 activity in the gut.

ABSTRACT: The coevolution of mammalian hosts and their beneficial commensal microbes has led to development of symbiotic host-microbiota relationships¹. Epigenetic machinery permits mammalian cells to integrate environmental signals²; however, how these pathways are fine-tuned by diverse cues from commensal bacteria is not well understood. Here we reveal a highly selective pathway through which microbiota-derived inositol phosphate regulates histone deacetylase 3 (HDAC3) activity in the intestine. Despite the abundant presence of HDAC inhibitors such as butyrate in the intestine, we found that HDAC3 activity was sharply increased in intestinal epithelial cells of microbiota-replete mice compared with germ-free mice. This divergence was reconciled by the finding that commensal b

SUBMITTER: Wu SE 

PROVIDER: S-EPMC7529926 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature