Severity of intervertebral disc herniation regulates cytokine and chemokine levels in patients with chronic radicular back pain.

ABSTRACT:

Objective

The contributions of intervertebral disc disease and subject-specific covariates to systemic inflammation in low back pain are unknown. We examined the effects of symptomatic disc herniation (DH) and MRI herniation severity on serum cytokine levels in clinical subjects.

Design

Cytokine levels from lumbar DH subjects (N = 78) were compared to control subjects (N = 57) accounting for effects of DH, age, body mass index (BMI) and gender. Effect of DH severity on cytokine levels was analyzed on subsets of subjects with acute or chronic pain. Serum cytokines were also analyzed in a subset of patients between pre- and 3 months post-surgery.

Results

Cytokine levels were elevated in the serum of patients with symptomatic DH, and the covariates age, BMI and gender si

SUBMITTER: Jacobsen HE 

PROVIDER: S-EPMC7529955 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature