A novel urinary biomarker protein panel to identify children with ureteropelvic junction obstruction - A pilot study.

ABSTRACT:

Introduction and objective

Reliable urinary biomarker proteins would be invaluable in identifying children with ureteropelvic junction obstruction (UPJO) as the existing biomarker proteins are inconsistent in their predictive ability. Therefore, the aim of this study was to identify consistent and reliable urinary biomarker proteins in children with UPJO.

Methods

To identify candidate biomarker proteins, total protein from age-restricted (<2 years) and sex-matched (males) control (n = 22) and UPJO (n = 21) urine samples was analyzed by mass spectrometry. Proteins that were preferentially identified in UPJO samples were selected (2-step process) and ranked according to their diagnostic odds ratio value. The top ten proteins with highest odds ratio values were selected and tes

SUBMITTER: Devarakonda CKV 

PROVIDER: S-EPMC7529974 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature