Fluorescent contact lens for continuous non-invasive measurements of sodium and chloride ion concentrations in tears.

ABSTRACT: Rapid and non-invasive measurement of hydration status is medically important because even mild levels of dehydration can have a significant impact on physical and cognitive performance. Despite the potential value of determining whole-body hydration based on the electrolytes found in tears, very few tests are available. An area of intense interest is the development of a contact lens which could measure ion concentrations in tears, specifically that of sodium (Na⁺) and chloride (Cl^-) ions, the dominant electrolytes in blood plasma and tears. Here, we describe a method to make fluorescent contact lenses which allow determination of Na⁺ and Cl^- ion concentrations in tears. Fluorophores known to be sensitive to Na⁺ and Cl^- wer

SUBMITTER: Badugu R 

PROVIDER: S-EPMC7530058 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature