Prenatal toxic metal mixture exposure and newborn telomere length: Modification by maternal antioxidant intake.

ABSTRACT:

Background

Telomere length (TL) predicts the onset of cellular senescence and correlates with longevity and age-related disease risk. While telomeres erode throughout life, adults display fixed ranking and tracking of TL, supporting the importance of the early environment in determining inter-individual variability across the life course. Given their guanine-rich structure, telomeres are highly susceptible to oxidative stress (OS). We examined maternal metal exposure, which can induce OS, in relation to newborn TL. We also considered the modifying role of maternal antioxidant intake.

Methods

Analyses included 100 mother-newborn pairs enrolled in the Boston and New York City-based PRogramming of Intergenerational Stress Mechanisms (PRISM) pregnancy cohort. We measured As, Ba,

SUBMITTER: Cowell W 

PROVIDER: S-EPMC7530067 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature