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Uncorking MCU to let the calcium flow.


ABSTRACT: New cryo-electron microscopy structures of the mitochondrial Ca2+ uniporter ion channel complex in various conformations reveal channel gating regulation by Ca2+-dependent unblock of the channel pore by MICU1.

SUBMITTER: Foskett JK 

PROVIDER: S-EPMC7530084 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Uncorking MCU to let the calcium flow.

Foskett J Kevin JK  

Cell calcium 20200728


New cryo-electron microscopy structures of the mitochondrial Ca<sup>2+</sup> uniporter ion channel complex in various conformations reveal channel gating regulation by Ca<sup>2+</sup>-dependent unblock of the channel pore by MICU1. ...[more]

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