Higher BMI is associated with smaller regional brain volume in older adults with type 2 diabetes.

ABSTRACT:

Aims/hypothesis

There are established relationships between adiposity (obesity) and higher dementia risk, faster cognitive decline and associated neural injury. Type 2 diabetes is strongly linked to greater adiposity and has been consistently associated with neural injury and poor cognitive outcomes. However, although obesity is a major cause of type 2 diabetes, there is limited evidence on the association of adiposity with brain atrophy among individuals with type 2 diabetes.

Methods

We examined the association of BMI (a measure of adiposity), and of long-term trajectories of BMI (three empirically identified groups of trajectories-'normal', 'overweight' and 'obese'-using SAS macro PROC TRAJ), with regional brain volume, in a sample of older individuals (aged 64-84) with ty

SUBMITTER: West RK 

PROVIDER: S-EPMC7530092 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature