Cancer Cell Coating Nanoparticles for Optimal Tumor-Specific Cytokine Delivery.

ABSTRACT: Although cytokine therapy is an attractive strategy to build a more robust immune response in tumors, cytokines have faced clinical failures due to toxicity. In particular, interleukin-12 has shown great clinical promise but was limited in translation because of systemic toxicity. In this study, we demonstrate an enhanced ability to reduce toxicity without affecting the efficacy of IL-12 therapy. We engineer the material properties of a NP to meet the enhanced demands for optimal cytokine delivery by using the layer-by-layer (LbL) approach. Importantly, using LbL, we demonstrate cell-level trafficking of NPs to preferentially localize to the cell's outer surface and act as a drug depot, which is required for optimal payload activity on neighboring cytokine membrane receptors. LbL-NPs showe

SUBMITTER: Barberio AE 

PROVIDER: S-EPMC7530125 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature