Cell Mechanics at the Rear Act to Steer the Direction of Cell Migration.

ABSTRACT: Motile cells navigate complex environments by changing their direction of travel, generating left-right asymmetries in their mechanical subsystems to physically turn. Currently, little is known about how external directional cues are propagated along the length scale of the whole cell and integrated with its force-generating apparatus to steer migration mechanically. We examine the mechanics of spontaneous cell turning in fish epidermal keratocytes and find that the mechanical asymmetries responsible for turning behavior predominate at the rear of the cell, where there is asymmetric centripetal actin flow. Using experimental perturbations, we identify two linked feedback loops connecting myosin II contractility, adhesion strength and actin network flow in turning cells that are sufficient

SUBMITTER: Allen GM 

PROVIDER: S-EPMC7530145 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature