Communications Between Peripheral and the Brain-Resident Immune System in Neuronal Regeneration After Stroke.

ABSTRACT: Cerebral ischemia may cause irreversible neural network damage and result in functional deficits. Targeting neuronal repair after stroke potentiates the formation of new connections, which can be translated into a better functional outcome. Innate and adaptive immune responses in the brain and the periphery triggered by ischemic damage participate in regulating neural repair after a stroke. Immune cells in the blood circulation and gut lymphatic tissues that have been shaped by immune components including gut microbiota and metabolites can infiltrate the ischemic brain and, once there, influence neuronal regeneration either directly or by modulating the properties of brain-resident immune cells. Immune-related signalings and metabolites from the gut microbiota can also directly alter the p

SUBMITTER: Liu F 

PROVIDER: S-EPMC7530165 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature