Increasing antiviral treatment uptake improves survival in patients with HBV-related HCC.

ABSTRACT:

Background & aims

Antiviral treatment is known to improve survival in patients with chronic hepatitis B (CHB)-related hepatocellular carcinoma (HCC). Yet, the treatment uptake in CHB patients remains low. We aimed to report the secular trend in antiviral treatment uptake from 2007-2017, and to compare the effect of different nucleos(t)ide analogue (NA) initiation times (before vs. after HCC diagnosis) on survival.

Methods

A 3-month landmark analysis was used to compare overall survival in patients not receiving NA treatment (i.e. no NA), patients receiving NAs after their first HCC treatment (i.e. post-HCC NA), and patients receiving NAs ≤3 months before their first HCC treatment (i.e. pre-HCC NA). A propensity score-weighted Cox proportional haza

SUBMITTER: Hui VW 

PROVIDER: S-EPMC7530304 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature