Computational assessment of MCM2 transcriptional expression and identification of the prognostic biomarker for human breast cancer.

ABSTRACT: Minichromosome maintenance protein 2 (MCM2) is a highly conserved protein from the MCM protein family that plays an important role in eukaryotic DNA replication as well as in cell cycle progression. In addition, it maintains the ploidy level consistency in eukaryotic cells, hence, mutations or alteration of this protein could result in the disintegration of the fine-tuned molecular machinery that can lead to uncontrolled cell proliferation. Moreover, MCM2 has been found to be an important marker for progression and prognosis in different cancers. Therefore, we aimed to analyze the MCM2 expression and the associated outcome in breast cancer (BC) patients based on the publicly available online databases. In this study, server-based gene expression analyses indicate the upregulation of MCM2 (

SUBMITTER: Samad A 

PROVIDER: S-EPMC7530310 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature