Urine biomarkers for monitoring acute kidney injury in premature infants.

ABSTRACT:

Background

Premature infants are at high risk for acute kidney injury (AKI). Serum creatinine (Cr) has limitations for evaluating kidney function in premature infants. We evaluated whether urine biomarkers could be used to monitor AKI in premature infants.

Methods

A prospective cohort study was conducted among infants born at < 37 weeks. Urine biomarkers and serum Cr were measured on postnatal days 1, 3, 5, 7, 10, and 14. Infants were divided into 3 groups according to gestational age (GA); < 28, 28 to < 32 and 32 to < 37 weeks.

Results

AKI occurred in 17 of 83 (20.5%) recruited infants at a median age of 7 (interquartile range 5-10) days. While the most common cause of AKI was hemodynamically significant patent ductus arteriosus (53.8%) in infants of GA < 28 weeks, n

SUBMITTER: Ahn YH 

PROVIDER: S-EPMC7530367 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature