Mitochondrial dysfunction in kidney injury, inflammation, and disease: Potential therapeutic approaches.

ABSTRACT: Mitochondria are energy-producing organelles that not only satisfy the high metabolic demands of the kidney but sense and respond to kidney injury-induced oxidative stress and inflammation. Kidneys are rich in mitochondria. Mitochondrial dysfunction plays a critical role in the progression of acute kidney injury and chronic kidney disease. Mitochondrial responses to specific stimuli are highly regulated and synergistically modulated by tightly interconnected processes, including mitochondrial dynamics (fission, fusion) and mitophagy. The counterbalance between these processes is essential in maintaining a healthy network of mitochondria. Recent literature suggests that alterations in mitochondrial dynamics are implicated in kidney injury and the progression of kidney diseases. A decrease i

SUBMITTER: Bhatia D 

PROVIDER: S-EPMC7530368 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature