Diverse CBX family members as potential prognostic biomarkers in non-small-cell lung cancer.

ABSTRACT: Chromobox (CBX) family members are vital epigenetic regulators that repress the transcription of target genes through chromatin modification. Several studies have investigated the role of CBX family members in cancer. However, the function and prognostic value of diverse CBX family members in non-small-cell lung cancer remain largely unknown. In this study, we reveal that CBX family members are overexpressed in non-small-cell lung cancer tissue compared with normal lung tissue, with the exception of CBX6. Kaplan-Meier analysis demonstrated that high expressions of CBX1 and CBX3 are correlated with overall survival, disease-specific survival, disease-free interval, and progression-free interval for patients with lung adenocarcinoma (LUAD). Furthermore, regression model analysis suggests tha

SUBMITTER: Xie X 

PROVIDER: S-EPMC7530393 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature