D-Dimer Combined with Fibrinogen Predicts the Risk of Venous Thrombosis in Fracture Patients.

ABSTRACT:

Objective

While D-dimer can successfully diagnose venous thrombosis due to its excellent negative predictive value (NPV), it cannot be used to detect venous thromboembolism (VTE) because of its low positive predictive value (PPV). This study aims to investigate if a combination of using D-dimer and fibrinogen can improve PPV in the VTE diagnosis.

Methods

We retrospectively analyzed various data including D-dimer, fibrinogen, C-reactive protein, ultrasound, and others collected from 10775 traumatic fracture patients and categorized them into two groups of VTE and non-VTE. By comparing the difference between the two groups, we employ multiple logistic regression to find risk factors that are useful to detect VTE. The receiver operating characteristic (ROC) curve was used to ev

SUBMITTER: Lin C 

PROVIDER: S-EPMC7530481 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature