Opioid Exposure Negatively Affects Antidepressant Response to Venlafaxine in Older Adults with Chronic Low Back Pain and Depression.

ABSTRACT:

Objective

Serotonin norepinephrine reuptake inhibitors (SNRIs) are commonly co-prescribed with opioids for chronic pain. The purpose of this study was to describe pain and mood response to venlafaxine among older adults with chronic low back pain (CLBP) and depression relative to opioid exposure.

Design

Secondary analyses were collected from a randomized clinical trial testing a stepped-care approach to comorbid pain and depression in older patients: the Addressing Depression and Pain Together study (ADAPT: 2010-2016).

Setting

University-based late-life mental health research clinic.

Subjects

Two hundred twenty-seven adults aged 65+ years with CLBP and depression.

Methods

Participants received six weeks of lower-dose venlafaxine (≤150 mg/d). Pain and dep

SUBMITTER: Stahl ST 

PROVIDER: S-EPMC7530569 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature