Mitochondrial dysfunction promotes aquaporin expression that controls hydrogen peroxide permeability and ferroptosis.

ABSTRACT: Most anti-cancer agents and radiotherapy exert their therapeutic effects via the production of free radicals. Ferroptosis is a recently described cell death process that is accompanied by iron-dependent lipid peroxidation. Hydrogen peroxide (H₂O₂) has been reported to induce cell death. However, it remains controversial whether H₂O₂-induced cell death is ferroptosis. In the present study, we aimed to elucidate the involvement of mitochondria in H₂O₂-induced ferroptosis and examined the molecules that regulate ferroptosis. We found that one mechanism underlying H₂O₂-induced cell death is ferroptosis, which occurs soon after H₂O₂ treatment (within 3 h after H₂O₂

SUBMITTER: Takashi Y 

PROVIDER: S-EPMC7530583 | biostudies-literature | 2020 Dec

REPOSITORIES: biostudies-literature