Top-ranked expressed gene transcripts of human protein-coding genes investigated with GTEx dataset.

ABSTRACT: With considerable accumulation of RNA-Seq transcriptome data, we have extended our understanding about protein-coding gene transcript compositions. However, alternatively compounded patterns of human protein-coding gene transcripts would complicate gene expression data processing and interpretation. It is essential to exhaustively interrogate complex mRNA isoforms of protein-coding genes with an unified data resource. In order to investigate representative mRNA transcript isoforms to be utilized as transcriptome analysis references, we utilized GTEx data to establish a top-ranked transcript isoform expression data resource for human protein-coding genes. Distinctive tissue specific expression profiles and modulations could be observed for individual top-ranked transcripts of protein-coding

SUBMITTER: Tung KF 

PROVIDER: S-EPMC7530651 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature