Short-term variability of the human serum metabolome depending on nutritional and metabolic health status.

ABSTRACT: The intra-individual variability of the human serum metabolome over a period of 4 weeks and its dependence on metabolic health and nutritional status was investigated in a single-center study under tightly controlled conditions in healthy controls, pre-diabetic individuals and patients with type-2 diabetes mellitus (T2DM, n = 10 each). Untargeted metabolomics in serum samples taken at three different days after overnight fasts and following intake of a standardized mixed meal showed that the human serum metabolome is remarkably stable: The median intra-class correlation coefficient (ICC) across all metabolites and all study participants was determined as 0.65. ICCs were similar for the three different health groups, before and after meal intake, and for different metabolic pathways. Only 1

SUBMITTER: Agueusop I 

PROVIDER: S-EPMC7530737 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature